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Milk basic protein : ウィキペディア英語版 | Milk basic protein Milk basic protein (MBP) is a fraction of whey protein found in milk.〔Möller, N.P., Scholz-Ahrens, K.E., Roos, N., & Schrezenmeir, J. (2008). Bioactive peptides and proteins from foods: indication for health effects. ''European Journal of Nutrition, 47''(4), 176.〕 Separated from milk through the process of fractionation, it is a functional compound〔Uenishi, K. (2006). Prevention of osteoporosis by foods and dietary supplements. Prevention of osteoporosis by milk and dairy products. ''Clinical Calcium, 16''(10), 10.〕 and consists of several milk proteins which are biologically active. The composition is approximately 54% lactoferrin and 41% lactoperoxidase,〔Kruger, C.L., Marano, K.M., Morita, Y., Takada, Y., Kawakami, H., Kobayashi, T., Sunaga, M., Furukawa, M., & Kawamura, K. (2007). Safety evaluation of a milk basic protein fraction. ''Food and Chemical Toxicology, 45'', 1301.〕 with other active proteins, such as Cyastin C and high mobility group-like proteins, making up the remainder of the fraction.〔Goodman, R., Taylor, S., Yamamura, J., Kobayashi, T., Kawakami, H., Kruger, C., & Thompson, G. (2007). Assessment of the potential allergenicity of a Milk Basic Protein fraction. ''Food and Chemical Toxicology, 45'', 1788.〕 MBP has been evaluated for safety and is intended for use as a dietary ingredient.〔 It is approved in Japan as a functional food ingredient in tofu and nattō. == Biological function == Active substances in the milk basic protein fraction promote bone formation and suppress bone resorption. It has been found to decrease the formation of osteoclast pits, which act to break down bone and release minerals for resorption into plasma, MBP helps to reduce this process.〔 It also increases bone mineralization by stimulating proliferation of osteoblasts which are involved in collagen production and bone formation.〔Kawakami, H. (2005). Biological significance of Milk Basic Protein (MBP) for bone health. ''FSTR, 11'', 1.〕 Daily supplementation with 40 mg of MBP over 6 months has been shown to result in increased bone mineral density and lower urinary markers of bone resorption.〔
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